Hidrate sodyum kalsiyum aluminosilikat içeren yemle beslenenetlik piliçlerde enrofloksasinin farmako kinetiği
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2005
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Sağlık Bilimleri Enstitüsü
Abstract
The Pharmacokinetics of Enrofloxacin in Broiler Chickens Fed with Feed Containing Hydrate Sodium Calcium Aluminosilicate. This research was aimed to determine whether the pharmacokinetics of enrofloxacin would show any changes in broiler chickens fed with feed including %1.5 HSCAS and normal feed (without HSCAS). For the study, Ross 308 strain, 28-day old, total 35 male chicks were used. Five main groups were designed (Group I-V) and 7 animals were used in each group. The animals in Group I, Group II and Group HI fed with normal feed (without HSCAS), in Group in and Group IV fed with feed including % 1.5 HSCAS for three days. 10 mg/kg enrofloxacin was given to Group I intravenous, to Group II and Group III intracrop, to Group IV and Group V in drinking water. Following the drug administration, the blood samples were taken into heparinased tubes at 0.083, 0.25, 0.5, 1., 1.5, 2, 4, 6, 8, 12, 18, 24, 30, and 36th hours from Group I and at 0.25, 0.5, 1, 1,5, 2, 4, 6, 8, 12, 18, 24, 30, and 36th hours from Groups II-V, in order to determine the plasma levels of the drug. The enrofloxacin concentration level in plasma was determined by agar-gel disc diffusion method. The plasma concentration-time curve, determined after the administration of enrofloxacin intravenous, showed that the drug distributed according to two-compartment open model. As pharmacokinetic parameters, when the drug was administrated by oral route (Groups II-V), compared to intravenous administration (Group I), there were the significant decreases (p<0, 05) in hybrid rate constant representing the slopes of distribution phase (a), hybrid rate constant representing the slopes of elimination phase (P), rate of drug passage from the central to the peripheral compartment (kn), rate of drug passage from the peripheral to the central compartment (k2i), drug elimination rate constants (kio) and the area under the concentration-time curve (AUC); there were the significant increases (p<0, 05) in hybrid rate constants representing distribution phase half-life (ti/2a), hybrid rate constants representing terminal phase half-life (ti^p), the average retention time of drug (MRT), distribution volume of central compartment (VI), distribution volume area (Vdarea) and plasma clearance (CI); when the drug administrated Group ITI intracrop, compared to Group II, there were the significant decreases (p<0,05) in t^p, MRT, Vd^ and AUC; there were the significant increases (p<0,05) in p and ti/2tt; when the drug is administrated to Group V in drinking water, compared to Group IV, there were the significant decreases (p<0,05) in tmp, vd^ and AUC; there were the significant increases (p<0,05) in p and absorption half-life (ti/2a); in Group IV, compared to Group II there were the significant decreases (p<0,05) in p, the maximum concentration in plasma after oral administration (Cma*) and AUC; there were the significant increases (p<0,05) in tiap, MRT and Vd^; in Group V compared to Group IH there were the significant decreases (p<0,05) in t\/2a and AUC; there were the significant increases (p<0,05) in ti^a, tj^p and Vdarea- The systemic bioavailability of enrofloxacin was 78,39% in Group II, 66,57% in Group m, 70,43% in Group TV and 48,67% in Group V. It was concluded that HSCAS which was supplemented to feed as an adsorbent made significant decrease in the absorption of the drug. The decrease in bioavailability of enrofloxacin was higher in drinking water administration than intracrop administration. The decrease observed in drinking water administration can be related with the receiving of the drug into the digestive system in low concentration with higher volume and the distribution40 of the drug in this system with high volume and because of this the gravity of the surface getting in touch with the adsorbent. It is important to know if there is an adsorbent in the feed in case of the enrofloxacin administration and to take precautions in this situation because of the prevalence of this drug via drinking water in herd treatment. Key Words: Pharmacokinetic, Enrofloxacin, Hydrate sodium calcium aluminosilicate, Broiler.
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Eczacılık ve Farmakoloji