Ratlarda gebeliğin değişik dönemlerinde trofoblastların özellikleri üzerinde histokimyasal ve immunohistokimyasal çalışmalar
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2004
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Sağlık Bilimleri Enstitüsü
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59 SUMMARY Histochemical and Immunohistochemical Investigation on Trophoblasts Characteristic in Different Stages of Pregnancy in Rats In this study, it's aimed to examine trophoblast cells and other placental structures histochemically and immunohistochemically in various periods of gestation in rats. Twenty adult, healty and pregnant rats were used as materials. It was observed that there were significant AB (+) reactions in syncytiotrophoblasts, PAS (+) in giant cells and cytotrophoblasts in the first half of gestation in histochemical examinations. In the second half of gestation, glycogen cells stained PAS/AB (+) coloured in purple granules and small basophilic cells showed gradually increasing AB (+) reactions. In the advanced state of gestations, decidual cells having vacuoles had PAS (+) reactions increasingly. In immunohistochemical examinations, hormonal activities increased significantly in trophoblasts and giant cells during the period staining from the implantation to the end of gestation. Oestrogen and progesterone receptors were found in high density in the cytoplasm and nucleus of the cells. Progesterone receptors decreased slightly towards the end of pregnancy, however, reactions were high in receptors belonging to both hormones. Key Words: Rat, Trophoblast, Placenta, Histochemistry, Immunohistochemistry.
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