Antioxidant and anticholinesterase activities of Juglans Regıa L. growing in Turkey
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Ankara : Ankara Üniversitesi
Abstract
Objective: World's ageing population continues to grow older together with high percentage prevalence
of Alzheimer's disease encourage science to find herbs or biologic compounds which can be utilized for it
prophylaxis. Juglans regia L. is not simply an agricultural product, its fruits, leaves, barks, stems, pericarps,
and flowers are all utilized for diversified medicinal usages. In the present investigation, we examined the
anticholinesterase and antioxidant capacities of the lyophilized aqueous extracts of leaves from J. regia.
Material and Method: Phenolic contents and antioxidant activity were assessed by Folin-Ciocalteu's,
qualitative/quantitative DPPH and TBA methods. Anticholinesterase activity was assessed by Ellman’s method.
Result and Discussion: The total phenolic content was found 478.32 mg/g. The extract indicated
antioxidant activity with DPPH test (IC50: 123.66 μg/mL) and TBA assay (IC50: 209.23 μg/mL). Moreover, the
extract of J. regia indicated remarkable inhibition towards acetylcholinesterase (40.09%) and
butyrylcholinesyterase (56.23%) enzymes. These data propose that J. regia can be utilised a potency for
pharmaceutical products which get antioxidant and anticholinesterase activity.
Description
Keywords
Antioxidant, Anticholinesterase, Juglans regia, Juglandaceae