Evaluation of the enrofloxacin excretion in Anatolian buffalo milk

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dc.contributor.authorİnce, Sinan
dc.contributor.authorAcaröz, Damla Arslan
dc.contributor.authorGürler, Zeki
dc.contributor.authorAcaröz, Ulaş
dc.contributor.departmentVeteriner Fakültesitr_TR
dc.date.accessioned2021-10-11T13:44:27Z
dc.date.available2021-10-11T13:44:27Z
dc.date.issued2021-03-31
dc.description.abstractEnrofloxacin (ENR) is a broad-spectrum fluoroquinolone antibiotic widely used in both human medicine and veterinary medicine. In this study, the milk-excretion patterns of ENR and its metabolite ciprofloxacin (CIP) were determined up to the 10th milking following the intramuscular administration of ENR (2.5mg/kg of body weight) to lactating dairy buffaloes. The milk of each animal was collected and the concentrations of ENR and CIP were detected in milk by LC-MS/MS. The detection limits of the method were determined for ENR and CIP as 0.35 μg/kg and 0.12 μg/kg, respectively. The highest total mean concentrations of ENR and its metabolite CIP was determined in the second milking after injection as 603 μg/kg. The residue level in all buffalo milk samples was found to be lower than the maximum residue limit (100 μg/kg) at the fifth milking. In addition, the employed method is successfully applied to evaluate the presence of ENR and CIP residue in 50 marketed buffalo milk samples and none of the samples contained these antibiotics. Consequently, the present study provided information on the milk excretion levels of ENR and CIP in Anatolian buffalo milks by an LC-MS/MS method.tr_TR
dc.identifier.endpage127tr_TR
dc.identifier.issn/e-issn1308-2817
dc.identifier.issue2tr_TR
dc.identifier.startpage121tr_TR
dc.identifier.urihttps://doi.org/10.33988/auvfd.706602tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/75380
dc.identifier.volume68tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesitr_TR
dc.relation.isversionof10.33988/auvfd.706602tr_TR
dc.relation.journalAnkara Üniversitesi Veteriner Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAnatolian Buffaloestr_TR
dc.subjectCiprofloxacintr_TR
dc.subjectEnrofloxacintr_TR
dc.titleEvaluation of the enrofloxacin excretion in Anatolian buffalo milktr_TR
dc.typeArticletr_TR

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Cilt:68 Sayı:02 (2021)