Kardiyopulmoner bypass uygulanan pediyatrik olgularda modifiye ultrafiltrasyonun sitokinler üzerindeki etkisi
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Date
2015
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Tıp Fakültesi
Abstract
Comparing serum cytokines (IL-1b,IL-6,IL-8,IL-10,TNF-α) and their effect on postoperative term in pediatric patients with congenital siyanotic/nonsiyanotic heart defect who underwent open heart surgery Materials and methods: In this study, we assessed 25 children who underwent pediatric cardiac surgery with cardiopulmonary bypass from September 2013 to August 2014. Patients who had redo cardiac surgery, preoperative organ disfunction, otoimmune disease, genetic disorders, shunt and emergency operations were excluded. Preand postoperative biochemical parameters, postoperativeurine output, chest tube drenaige, diüretic usage, blood and bloodproduct transfusion, dialysis requirement and mortality were compared. Results: İn our study we found that level of IL-6,IL-8,IL-10 an TNF-α was highest after MUF. IL-1b wast highest 1 hour after operation. IL-1b,IL-10 and TNF-α does not effect extubation time. IL-6 and IL-8 effect ekstubation time negatively. (p<0,05) Conclusions: Hemodynamic, pulmonary, hematologic and immunologic effects of modified ultrafiltration are well known. Although our study group was not big enough to get a conclusion, we believe that modified ultrafiltration can not decrease the level of serum cytokines because of hemoconsantration.
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modifiye ultrafiltrasyon, kardiyopulmoner baypas, pediatrik açık kalp cerrahisi