Investigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: Discussion on possible antioxidant mechanisms and comparison with melatonin

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherBozkaya, Pinar
dc.contributor.otherÇoban, Tülay
dc.contributor.otherNebioǧlu, Doǧlu
dc.date.accessioned2020-03-17T13:30:43Z
dc.date.available2020-03-17T13:30:43Z
dc.date.issued2006
dc.description.abstractOxidative stress has been implicated in the development of many neurodegenerative diseases and also responsible from aging and some cancer types. Indolic compounds are a broad family of substances present in microorganisms, plants and animals. They are mainly related to tryptophan metabolism, and present particular properties that depend on their respective chemical structures. Due to free radical scavenger and antioxidant properties of indolic derivatives such as indolinic nitroxides and melatonin, a series of 2-phenyl indole derivatives were prepared and their in vitro effects on rat liver lipid peroxidation levels, superoxide formation and DPPH stable radical scavenging activities were determined against melatonin, BHT and α-tocopherol. The compounds significantly inhibited (72-98%) lipid peroxidation at 10-3 M. These values were similar to that observed with BHT (88%). Possible structure-activity relationships of the compounds were discussed.tr_TR
dc.description.indexwos
dc.description.indexScopus
dc.identifier.endpage411tr_TR
dc.identifier.issue4tr_TR
dc.identifier.startpage405tr_TR
dc.identifier.urihttps://doi.org/10.1080/14756360500381210tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70706
dc.identifier.volume21tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1080/14756360500381210tr_TR
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistrytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subject2-phenylindolestr_TR
dc.subjectAntioxidant mechanismtr_TR
dc.subjectFree radicalIndolestr_TR
dc.subjectLipid peroxidationtr_TR
dc.subjectSynthesistr_TR
dc.titleInvestigation of the in vitro antioxidant behaviour of some 2-phenylindole derivatives: Discussion on possible antioxidant mechanisms and comparison with melatonintr_TR
dc.typeArticletr_TR

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