Plasma amino-terminal propeptide of C-type natriuretic peptide concentration in normal-weight and obese children

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dc.contributor.advisorAkyol, Mesut
dc.contributor.advisorOrhon, Filiz Şimşek
dc.contributor.authorTopçu, Seda
dc.contributor.departmentTıp Fakültesitr_TR
dc.contributor.otherÖzhan, Bayram
dc.contributor.otherAlkan, Afra
dc.contributor.otherBaşkan, Sevgi
dc.contributor.otherUlukol, Betül
dc.date.accessioned2020-03-19T12:45:06Z
dc.date.available2020-03-19T12:45:06Z
dc.date.issued2017
dc.description.abstractObjective: In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population. Methods: Consent was taken from 317 children [ages 0-18 (158 girls, 159 boys)] and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay. Results: Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty. Conclusion: Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question.tr_TR
dc.identifier.endpage314tr_TR
dc.identifier.issue4tr_TR
dc.identifier.startpage308tr_TR
dc.identifier.urihttps://doi.org/10.4274/jcrpe.4543tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70740
dc.identifier.volume9tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.4274/jcrpe.4543tr_TR
dc.relation.journalJ Clin Res Pediatr Endocrinoltr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectC-type natriuretic peptidetr_TR
dc.subjectAmino-terminal propeptide of C-type natriuretic peptidetr_TR
dc.subjectObesitytr_TR
dc.subjectOverweighttr_TR
dc.subjectGrowthtr_TR
dc.subjectBiomarkertr_TR
dc.titlePlasma amino-terminal propeptide of C-type natriuretic peptide concentration in normal-weight and obese childrentr_TR
dc.typeArticletr_TR

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