Antimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamide

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.contributor.otherSirinzadeh, Hanif
dc.contributor.otherAltanlar, Nurten
dc.contributor.otherWestwell, Andrew D.
dc.date.accessioned2020-03-17T13:12:27Z
dc.date.available2020-03-17T13:12:27Z
dc.date.issued2018
dc.description.abstractObjectives: In new antimicrobial drug development studies, indole and its derivatives create an important class of compounds. In addition, azoles and their derivatives were recognized to be associated with a variety of biologic activities such as antibacterial and antifungal. In this study antimicrobial activities of some indole derivatives mainly substituted with 1,2,4-triazole, 1,3,4-thiadiazole and hydrazinecarbothioamide were investigated to evaluate their efficacy. Materials and Methods: The efficacy of new compounds was evaluated using 2-fold serial dilutions against Staphylococcus aureus, MRSA, Escherichia coli, Bacillus subtilis, Candida albicans, and Candida krusei. Results: The MIC was determined for test compounds and for the reference standards sultamicillin, ampicillin, fluconazole, and ciprofloxacin. Conclusion: The compounds possessed a broad spectrum of activity having MIC values of 3.125-50 µg/mL against the tested microorganisms. This study provides valuable evidence that the indole-triazole derivative compound 3d holds significant promise as a novel antibacterial and antifungal lead compound.tr_TR
dc.identifier.endpage297tr_TR
dc.identifier.issn/e-issn1304-530X
dc.identifier.issue3tr_TR
dc.identifier.startpage291tr_TR
dc.identifier.urihttps://doi.org/10.4274/tjps.55707tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70701
dc.identifier.volume15tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.4274/tjps.55707tr_TR
dc.relation.journalTurk J Pharm Scitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectIndole,tr_TR
dc.subject1, 2, 4-triazole,tr_TR
dc.subject1, 3, 4-thiadiazole,tr_TR
dc.subjectMRSA, C. kruseitr_TR
dc.titleAntimicrobial Activities of New Indole Derivatives Containing 1,2,4-Triazole, 1,3,4-Thiadiazole and Carbothioamidetr_TR
dc.typeArticletr_TR

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